Mechanism of Vitamin D Action The WritePass Journal

Mechanism of Vitamin D Action Introduction Mechanism of Vitamin D Action ) also retaliates that once peak bone mass is reached, adults lacking vitamin D in their system will annually loose approximately 0.5% of their skeletal mass if they lack sufficient vitamin D and calcium in their systems (p.18). In addition, vitamin D deficiency can also lead to osteomalacia (DeLuca Schnoes, 1976); a mineralization defect of the collagen matrix. This condition is often accompanied by throbbing bone pain and aching (DeLuca Schnoes, 1976). Holick (2010) points out another research at the University of Pittsburgh that also established a correlation between vitamin D deficiency and increased susceptibility to bone fractures. The study measured the vitamin D levels of 400 participants with hip fractures and compared the results with the vitamin D levels of 400 other healthy women. The outcome demonstrated that individuals with the lowest levels of Vitamin D were 71 percent susceptible to bone fractures compared to those with the highest levels of vitamin D. Consequently, the role played by vitamin D in sustaining bone health can never be overemphasized. Not only does it aid in mineral absorption and bone development in intrauterine growth and childhood, but is also responsible for strong bones in adults as well. References DeLuca, H, F., and Schnoes K.K., (1976). Metabolism and Mechanism of Action of Vitamin D. Annual Review of Biochemistry. Vol. 45: 631- 637 Holick, M.F., (2010). Vitamin D: Physiology, Molecular Biology, and Clinical Applications. New York: Springer Science Business Media Watson, R.S., (2013). Handbook of Vitamin D in Human Health: Prevention, Treatment and Toxicity, Chicago: Wageningen Academic Pub.